Just popping in 
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I play Commander Keen 4 here sometimes, works just fine. Make sure the cpu cycles are set correctly, not to high and not too low. DOS games with sound often have to be configured first, make sure the settings in the game matches the ones in dosbox.conf, and about the mouse i have no idea. Though there is this in the conf file:
# autolock -- Mouse will automatically lock, if you click on the screen. # sensitivity -- Mouse sensitivity.
autolock=false sensitivity=100
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